Peter Nissen Bjerring
Curriculum vitae
Research activities and relations:
Peter Nissen Bjerring has conducted research in the Department of Hepatology, Rigshospitalet, Denmark since 2006 and is involved in several projects related to liver failure and encephalopathy. Peter Nissen Bjerring has published articles on clinical studies using the technique of cerebral microdialysis in patients with acute liver failure and animal models of encephalopathy - currently 17 peer-reviewed papers and an H-index=7. Peter Nissen Bjerring has used animal models to study both brain signaling during liver failure and the effect of pharmacological intervention based on the current understanding of the pathophysiology involved in brain oedema formation during hepatic encephalopathy. Peter Nissen Bjerring has collaborated and co-authored with Prof. Nicholas Dale from University of Warwick, School of Life Sciences, UK and is currently working on a clinical project with focus on hepatic encephalopathy and sleep disorders in collaboration with Sara Montagnese, University of Padua, Italy.
Peter Nissen Bjerring is a member of the Danish Society for Gastroenterology and Hepatology (DSGH) and is also a member of the European Association for the Study of the Liver (EASL) and the Editorial Board of the peer-reviewed paper World Journal of Hepatology.
Present and most recent positions:
September 2017-: Consultant in Hepatology and Gastroenterology, Medical Section at Amager and Hvidovre Hospital.
September 2014-August 2017: Department of Gastroenterology, Medical Section at Amager and Hvidovre Hospital, Hvidovre, Denmark.
June 2013-August 2014: Departments of Hepatology and Gastroenterology, Rigshospitalet, Copenhagen, Denmark.
March 2012-May 2013: Department of Endocrinology and Gastroenterology, Bisbebjerg Hospital, Copenhagen, Denmark.
Research fellow:
March 2008-January 2012: Department of Hepatology, Rigshospitalet, Copenhagen, Denmark
Publications
Peer reviewed articles:
-Cerebral blood flow and metabolism in hepatic encephalopathy - a meta-analysis. Bjerring PN, Larsen FS, Gluud LL. Journal of Clinical and Experimental Hepatology. Accepted June 2018.
-Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release. Bjerring PN, Bjerrum EJ, Larsen FS. J Hepatol. 2018 Jun;68(6):1137-1143.
-Witt AM, Larsen FS, Bjerring PN. Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. Metab Brain Dis. 2016 Dec 7. [Epub ahead of print]
-Bernal W, Murphy N, Brown S, Whitehouse T, Bjerring PN, Hauerberg J, Frederiksen HJ, Auzinger G, Wendon J, Larsen FS. A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure. J Hepatol. 2016 Mar 12.
-Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triantafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J.
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol. 2016 Jan;64(1):69-78.
-Rohde J, Pedersen HR, Bjerring PN, Larsen FS. Effects of dexamethasone and cox inhibitors on intracranial pressure and cerebral perfusion in the lipopolysaccharide treated rats with hyperammonemia. PLoS One. 2015 Feb 12.
-Bjerring PN, Dale N, Larsen FS. Acute Hyperammonemia and Systemic Inflammation is Associated with Increased Extracellular Brain Adenosine in Rats: A Biosensor Study. Neurochem Res. 2015 Feb;40(2):258-64.
-Larsen RH, Kjær MS, Eefsen M, Larsen FS, Bjerring PN. Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia. World J Hepatol. 2013 Sep 27;5(9):513-20.
-Bjerring PN, Larsen FS. Changes in cerebral oxidative metabolism in patients with acute liver failure. Metab Brain Dis. 2012 Oct 26.
-Bjerring PN, Hauerberg J, Frederiksen HJ, Nielsen HB, Clemmesen JO, Larsen FS. The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. J Hepatol. 2012 Oct;57(4):774-9.
-Bjerring PN, Eefsen M, Larsen FS, Bernal W, Wendon J. Hypermagnesemia does not prevent intracranial hypertension and aggravates cerebral hyperperfusion in a rat model of acute hyperammonemia. Hepatology. 2011 Jun;53(6):1986-94.
-Larsen FS, Bjerring PN. Acute liver failure. Curr Opin Crit Care. 2011 Apr;17(2):160-4. Review.
-Bjerring PN, Hauerberg J, Jorgensen L, Frederiksen HJ, Tofteng F, Hansen BA, Larsen FS. Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. J Hepatol. 2010 Dec;53(6):1054-8.
-Bjerring PN, Eefsen M, Hansen BA, Larsen FS. The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. Metab Brain Dis. 2009 Mar;24(1):5-14. Review.
-Bjerring PN, Hauerberg J, Frederiksen HJ, Jorgensen L, Hansen BA, Tofteng F, Larsen FS. Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. Neurocrit Care. 2008;9(1):3-7.
-Larsen FS, Vainer B, Eefsen M, Bjerring PN, Adel Hansen B. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. World J Gastroenterol. 2007 Jun 21;13(23):3232-6.
-Bjerring PN, Jacobsen O, Biagini M, Skjoldbye B, Horn T. [Focal nodular hyperplasia]. Ugeskr Laeger. 2007 Jan 29;169(5):410-4. Danish.
Book chapters
Danish textbook for nurses
Chapter 3. Cancer, definition, epidemiology, aetiologies, diagnostics and treatment. Peter Nissen Bjerring
E-book chapter: Critical Care in Acute Liver Failure
Chapter 8: Management of encephalopathy and cerebral edema: Fin Stolze Larsen, Peter Nissen Bjerring
E-book chapter: Liver Failure: Etiologies, Neurological Complications and Emerging Therapies
Chapter 3. Hepatic Encephalopathy, Cerebral Blood Flow and the Changes in Oxidative Metabolism. Peter Nissen Bjerring, Fin Stolze Larsen
